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JEM staff members are working remotely in line with New York City’s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JEM staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.

Newest Articles

Article

| July 31 2022

GATA2-regulated developmental trajectories

Kirby D. Johnson, Daniel J. Conn, Evgenia Shishkova, Koichi R. Katsumura, Peng Liu, Siqi Shen, Erik A. Ranheim, Sean G. Kraus, Weixin Wang, Katherine R. Calvo, Amy P. Hsu, Steven M. Holland, Joshua J. Coon, Sunduz Keles, Emery H. Bresnick

By elevating levels of the GATA2 transcription factor in hematopoietic progenitor cells, a transcriptional enhancer establishes multilineage differentiation potential. During embryogenesis, deleting the enhancer upregulates innate immune machinery and deconstructs multilineage potential to favor monocytic differentiation.

Article

| July 29 2022

The existence of a circulating CD8 + T RM precursor

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Following local inflammation, CD8+ T cells develop into tissue-resident memory T cells (TRM). Through combined lineage tracing and single-cell transcriptome analysis, the authors show that the circulating T cell pool harbors TRM precursors that commit to the TRM fate before tissue entry.

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Brief Definitive Report

| July 29 2022

Aberrant AKT activation drives ganglioneuroma

锐速破解版一键安装包 | 厘米天空:2021-4-7 · 大概2月份的时候锐速宣布不再免费，原来宣传的永久免费20M也没了。一时间让广大vps爱好者陷入低谷，不过各路破解高手也是不断抛砖引玉，从开始的改MAC方法到后来的算lic方法，现在连一键安装包都出来了，算是比较成熟了吧。这里转载一个用的比较多的一键安装包，亲测可用，由91yun.org博 …

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Brief Definitive Report

| July 28 2022

A defect in STING trafficking causes COPA syndrome

Zimu Deng, Zhenlu Chong, Christopher S. Law, Kojiro Mukai, Frances O. Ho, Tereza Martinu, Bradley J. Backes, Walter L. Eckalbar, Tomohiko Taguchi, Anthony K. Shum

A defect in COPI transport due to mutant COPA causes multimerization of STING on the Golgi and type I interferon–driven immune dysregulation in mice. Small-molecule inhibition of STING activation is a new molecular target for treating COPA syndrome.

Brief Definitive Report

| July 28 2022

Plasma p-tau isoforms’ utility for AD diagnosis

Nicolas R. Barthélemy, Kanta Horie, Chihiro Sato, Randall J. Bateman

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| July 28 2022

COPA regulates interferon signaling through STING

Alice Lepelley, Maria José Martin-Niclós, Melvin Le Bihan, Joseph A. Marsh, Carolina Uggenti, Gillian I. Rice, Vincent Bondet, Darragh Duffy, Jonny Hertzog, Jan Rehwinkel, Serge Amselem, Siham Boulisfane-El Khalifi, Mary Brennan, Edwin Carter, Lucienne Chatenoud, Stéphanie Chhun, Aurore Coulomb l’Hermine, Marine Depp, Marie Legendre, Karen J. Mackenzie, Jonathan Marey, Catherine McDougall, Kathryn J. McKenzie, Thierry Jo Molina, Bénédicte Neven, Luis Seabra, Caroline Thumerelle, Marie Wislez, Nadia Nathan, Nicolas Manel, Yanick J. Crow, Marie-Louise Frémond

Heterozygous missense mutations in COPA underlie constitutive interferon signaling through STING, thereby defining a novel type I interferonopathy and emphasizing the importance of the ER–Golgi axis in interferon homeostasis. Based on these results, three patients have been treated with interferon signaling (JAK1) inhibitors.

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Article

| July 27 2022

Proteome-wide profiling of HPV-specific T cell immunity

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Proteome-wide profiling of HPV-specific T cell immunity in oropharyngeal cancer (OPC) patients reveals broad and multiple antigen-specific reactivities directed to HPV-encoded proteins E1, E2, E4, E5 E6, E7, and L1. These observations provide novel insights for future development of cellular immunotherapies for HPV-associated OPC patients.

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Volume 217,

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People & Ideas

| July 31 2022

Lessons of COVID-19: Virtual conferences

Stephanie Houston

Lessons of COVID-19: Virtual conferences

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Viewpoint

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Lessons in pandemic times

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Insights

| July 22 2022

Talin1 affects migration and TLR signaling in DCs

Björn E. Clausen

In dendritic cells, talin1 links integrin binding to efficient TLR downstream signaling through interaction with MyD88 and PIP5K.

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Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8⁺ T cells

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

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